30 CATHOLIC PRAYER FOR HEADACHES Headache is an unpleasant pain that affects the head region, causing discomfort and problems to the head. Headache can occur due to several reasons, a number of them are discussed below: Stress: Too much work and exhaustion can cause headache and a feeling of discomfort. The body system reacts to activities in different ways, and an headache can be a reaction to stress and exhaustion. Illness: Headache can occur as a symptom of another illness